Developing cutting-edge solutions using MACS technology to combat cancer and antibiotic-resistant bacteria. Our innovations focus on creating new molecules that inhibit the growth of cancer cells and superbugs, providing advanced medical treatments.
Amino acids are essential nutrients for all living cells, especially in cancer cells. Due to the characteristics of rapid growth and replication of cancer cells, the demand for amino acids is higher than that of normal cells.
Unlike the strategy of starving cancer cells with anticancer drugs that block their source of nutrition, we do the opposite. We took advantage of the characteristics of amino acid requirements of cancer cells and applied the MACS system to create novel anticancer molecules. Due to the amino acid backbone, the molecule can be taken up into cells via amino acid transporters, eventually inducing apoptosis in cancer cells.
AmelioBio, through its MACS technology, has developed novel substances that effectively target G-quadruplexes (G4) structures found in human DNA and RNA. These structures are crucial in various biological processes such as gene regulation and chromosome maintenance. G4 structures are particularly prominent in cancer gene promoters, viral genomes, and antibiotic-resistant bacteria, making targeting these structures a promising therapeutic strategy. Our research shows that substances produced by MACS can stabilize these structures, thereby inhibiting disease-related gene expression or viral replication, offering new hope in combating major diseases.
MACS enables rapid coupling of amino acids with highly water-insoluble metal molecules.
MACS is a synthesis technology that produces pure products without contaminating by-products.
MACS demonstrates the ability of molecules to self-assemble in aqueous environments, yielding products with high water solubility. This high solubility and bioavailability potential make it highly promising for biomedical applications.